Her first foray into the mainstream adult film industry came in 1998, when she appeared in the Jules Jordan film New Breed. She was the Penthouse Pet of the month in January 2001.
Devon worked for Vivid for three years (1998-2001). Her first release for Vivid was Country Comfort. After her Vivid contract, Devon signed with Digital Playground. In 2004, Devon appeared in the first WMV-HD DVD porn movie ever made, Island Fever 3, filmed on Tahiti and Bora Bora. In 2005, she co-starred in the adult film Pirates.
By January 2006, she signed with a new company, Ecstasy Mobile. In March 2006, she signed with Black Kat Productions, which never produced any films with Devon. Devon then formed her own production company. In October 2006, she signed a contract with Shane's World to appear in films and direct film scenes for the company. She made her directorial debut for Shane's World in April 2007 with the title Devon Does Baja. She claims she is personally most proud of Virtual Sex with Devon (2001), recollecting that she spend more work filming that title than most other titles.
In 2010, Devon was inducted into the Adult Video News Hall of Fame.
